Research recently showed a connection between Propecia and also the loss of sexual libido, erection dysfunction, depression and thoughts of suicide.
The effects from Propecia, previously referred to as finasteride, seemed to have stopped after discontinuation of the medication. However, half the normal commission of males are thought to have long-lasting sexual negative effects from the drug. Based on NBC News, 64 percent of the men in the study stated that they long-term sexual negative effects because of the drug. Additionally they described the signs of depression, with 40 % noting that they thoughts of suicide. The findings were published recently in the Journal of Clinical Psychiatry.
“The potential life-threatening side-effects associated with finasteride should prompt clinicians to possess serious discussions using their patients,” Dr. Michael Irwig of George Washington University told NBC News.
In the work, the investigators interviewed 61 young men. The average age of the males was 25 and all sorts of had used Propecia. All the participants had reported sexual side effects three months or even more after discontinuing the medication. Before taking the medication, they had not had any sexual problems and didn’t show indications of mental history previously. Another number of men, those with male-pattern baldness who hadn’t taken the medication, were also interviewed; this group later on had become the control group.
According to the Huffington Post, they also gathered additional information on the subjects. They collected data on the participants´ demographic information, medical and psychiatric state, and anything associated with drinking, medication use, and sexual function. All the participants were asked about their the signs of depression on the two-week period as well as self-administered the Beck Depression Inventory II, which is often used to estimate the level of depression in grown-ups.
For those who had used the medication, 11 percent reported that they mild symptoms of depression, 28 percent had moderate symptoms, and three percent had significant symptoms. Too, 39 percent stated that they suicidal thoughts. For individuals who had not used the medication, there have been less many reports of feelings of depression; 10 percent had mild symptoms, while none had moderate or significant symptoms. Only three percent of this group discussed their thoughts of suicide.
Based on these results, there´s possible that Propecia caused the signs of depression by modifying the amount of certain brain chemicals. Propecia can move across the blood-brain barrier. In the brain, it stops an enzyme that changes the amount of hormone-derived neuroactive steroids, affecting anxiety and depression.
“A plausible biological mechanism to explain the association between [Propecia] and depression lies with neuroactive steroids, neuromodulators that are synthesized within the nervous system itself and that will also be transported to the brain from the gonads and adrenals,” Irwig commented in an article by MedPage Today. “Although the results of [Propecia] within the mind are poorly understood, clinicians, in addition to potential [Propecia] users, should know the serious potential perils of medicines, especially because it is being used cosmetically to change an ordinary age-related process.”
Researchers think that doctors need to be conscious of the possible perils of taking the drug. Furthermore, more research is required to confirm the results. While there has been research done on older men with erection dysfunction, there’s been less research done on depression related to erectile dysfunction in young males. As such, the findings from the study are thought preliminary at the moment.