Kaitlin Hunter of Marietta GA, after a near-fatal car crash, found herself fighting for her life against a clostridium difficile (C. diff) infection in her colon due to the June 2011 motor vehicle accident.
Emergency crews had to cut Hunter from her dad´s car and then she was flown to some hospital, where she found herself recovering for weeks afterwards from the fractured spine, lacerated liver and colon, and 10 broken toes.
In the hospital after her accident, doctors followed standard care and set Hunter on antibiotics to avoid an infection, reports William Hudson for CNN. And it was at spite from the antibiotics or possibly because of them when C. diff infected her colon, causing severe stomach pain, diarrhea and vomiting.
C. diff infections kill about 14,000 individuals america each year, according to the Centers for Disease Control and Prevention, and also the number and severity of total cases have raised dramatically over the past decade.
Antibiotics are designed to kill harmful, infection-causing bacteria, but can also weaken the beneficial bacteria percolating in the colon. With the colon´s defenses down, C. diff grows rampant, releasing a toxin and inflaming the colon.
Hunter´s colon infection proved hard to treat, despite 9 rounds of antibiotic treating her, but was finally beaten via a little-known technique relating to the transplant of feces, which put healthy bacteria back into her colon.
More and more doctors are searching for treatments that decrease the quantity of antibiotics introduced into a patient, understanding that the risk increases for that infections being immune to them. Fecal matter transplants are becoming more accepted and successful constantly, as they recolonize the colon with new bacteria from the healthy donor.
“This really is brand-new for many gastroenterologists,” said Dr. Suku George, Hunter´s treating physician. “We’re very excited about this.”
George had not deposited feces by colonoscopy right into a patient until Hunter desired to check it out. Hunter´s mother “donated” one of her stools for that procedure. Next, a healthcare facility lab carefully diluted it and George pumped the foreign fecal matter directly into Hunter´s colon, producing a successful ending of Hunter´s struggle with the bacteria.
A study published in March of the year reported a 91% cure rate after just one feces transplant along with a 98% cure rate when coupled with an additional round of antibiotics.
Remarkably, that study only included the sickest of patients with 77 of the study participants suffering a recurring C. diff infection after you have tried and failed five rounds of antibiotic-only treatments over 11 months, on average.
The study used the colonoscopy method with its relatively considerable amounts of feces placed insidewithin all the colon. This really is thought to be the most effective method.
Other methods use either an enema or a nasogastric tube, which sends feces through the nasal passage, on the throat and into the stomach.
After attempting the nasogastric tube procedure on Hunter, using fecal material from her father, the C. diff infection returned. George asked for and received permission to do the hospital´s first colonoscopic fecal transplant.
Gastroenterologists pioneering the practice would like to see a cleaner, commercially developed suppository to replace the crude feces and water mixtures currently being used. “It´ll become a a bit more acceptable to hospitals and patients and much more widely performed,” said Dr. Lawrence Brandt, a professor of drugs and surgery at New York´s Albert Einstein College of Medicine who had been the lead author from the March study.
“But for people that have recurring C. diff, it doesn´t really much matter, since these people are so ill and thus much would like to get better. The fact that it´s stool, it doesn´t matter to them.”